Thesis (Ph.D.) - University of Birmingham, Institute for Cancer Studies, Faculty of Medicine and Dentistry.
|Statement||by Ian Ashmole.|
The role of E4 in aiding virus release is supported by the association of E4 with the CCE, which is a highly resistant structure beneath the plasma membrane of differentiated keratinocytes in the stratum corneum. It comprises cross-linked proteins, including loricrin, involucrin, small proline-rich proteins. In general, the E4 proteins are expressed before L2 and L1, with their structure and function being modified, first by kinases as the infected cell progresses through the S and G2 cell cycle phases, but also by proteases as the cell exits the cell cycle and undergoes true terminal differentiation. E4 protein is a cytoplasmic protein disturbing the structural framework of keratin. It is sometimes detected in the cell nucleus, and it influences the formation of the HPV-1 triggered nodules. Its role in the regulation of cell cycle may also be by: Mucosal human papillomaviruses infections. The association of HPV with cervical disease has been extensively studied. HPV detection in the absence of apparent disease is found in 11–12% of all women. Detection is higher in young women ((and men) 50–80% 36) and declines in Cited by:
The E1 E4 protein of human papillomavirus type 16 (HPV16) causes cytokeratin reorganization in the modulate high-risk E1 E4 structure and function during the In this study. In general, the E4 proteins are expressed before L2 and L1, with their structure and function being modified, first by kinases as the infected cell progresses through the S and G2 cell cycle. Protein E4. Gene. E4. Organism. Human papillomavirus type 6a. Status. Reviewed-Annotation score: The major E4 form is first synthesized as an E1^E4 fusion protein from spliced E1^E4 transcripts, such that the first few amino acids of the E4 protein . The human papillomavirus (HPV) is a relatively small non-enveloped virus that contains a double-stranded closed circular DNA genome, associated with histone-like proteins and protected by a capsid formed by two late protei ns, L1 and Size: KB.
Protein E4. Gene. E4. Organism. Human papillomavirus type Status. Reviewed-Annotation score: The major E4 form is first synthesized as an E1^E4 fusion protein from spliced E1^E4 transcripts, such that the first few amino acids of the E4 protein . Interestingly, the viral E4 protein has some characteristics of a core protein, in that it is present in most if not all papillomaviruses, but is also variable at the primary amino acid sequence level, which at first site could suggest a divergent function. It is thought however that E4 plays a key role in virus escape from the cornified Cited by: Viral Structure Human papillomavirus is a small, non-enveloped, double-stranded DNA virus that is approximately 55 nm in diameter and a member of the Papillomaviridae family.[3,21] The viral DNA genome encodes eight open reading frames comprised of six early (E1, E2, E4, E5, E6, E7) proteins that maintain regulatory function (and. The Human Papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected by: